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上海醫藥(601607.SH):不超11.5億元取得T3011(瘤內注射)項目在大中華地區商業化的獨家權益
格隆匯 08-06 18:23

格隆匯 8 月 6日丨上海醫藥(601607.SH)公佈,202086日,公司深圳市亦諾微醫藥科技有限公司(亦諾微)簽訂授權許可協議》,不超過人民幣11.5億元取得T3011(瘤內注射)項目大中華地區(中國大陸、香港、澳門以及台灣)商業化的獨家

T3011新一代的溶瘤HSV病毒產品,採用了專有的病毒骨架並且插入獨特的細胞因子組合(IL-12PD-1抗體)兼顧安全性的同時提高了病毒的力,進一步強化了免疫協同抗腫瘤作用

瘤病毒是一種病毒特異性感染並殺傷腫瘤細胞的新型腫瘤療法,通過直接裂解腫瘤細胞激發機體系統性的抗腫瘤免疫反應從作用機理來看,溶瘤病毒具有與化療、放療、靶向藥物、免疫治療等多種腫瘤療法協同聯用增效的潛力,並且可作為一種基因遞送的載體工具。

T3011(瘤內注射)項目國內IND申請已於20198月獲批,正在上海復旦大學腫瘤醫院等機構開展針對實體瘤適應症的I期臨牀試驗,目前已入組患者。同時,T3011(瘤內注射)項目的美國IND已於20205月獲得美國FDA批准。

目前全球已經上市的溶瘤病毒產品包括美國Amgen公司的T-VEC上海三維生物技術有限公司的安柯瑞根據Evaluate Pharma數據庫,2019溶瘤病毒產品全球銷售額為0.68億美元

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