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恆瑞醫藥(600276.SH)與GSK達成協議 恆瑞將有資格獲得潛在總金額約120億美元

格隆匯7月28日丨恆瑞醫藥(600276.SH)公佈,公司與GSK達成協議,將HRS-9821項目的全球獨家權利(不包括中國大陸、香港特別行政區、澳門特別行政區及臺灣地區)和至多11個項目的全球獨家許可的獨家選擇權(不包括中國大陸、香港特別行政區、澳門特別行政區及臺灣地區)有償許可給GSK。

根據協議,GSK將向恆瑞支付5億美元的首付款。如果所有項目均獲得行使選擇權且所有里程碑均已實現,恆瑞將有資格獲得未來基於成功開發、註冊和銷售里程碑付款的潛在總金額約120億美元。恆瑞將有權向GSK收取相應的分梯度的銷售提成(不包括中國大陸、香港特別行政區、澳門特別行政區和臺灣地區)。

據悉,HRS-9821是一款潛在的同類最佳PDE3/4抑制劑,目前正處於臨牀開發階段,可用於治療慢性阻塞性肺病(COPD),作爲輔助維持治療,無需考慮既往治療方案。該藥物已在早期臨牀和臨牀前研究中顯示出強效的PDE3和PDE4抑制作用,從而增強支氣管擴張和抗炎作用,併爲開發便捷的乾粉吸入器(DPI)製劑提供了機會。 

其他11個項目涉及腫瘤、呼吸、自免和炎症等多個治療領域的創新藥物,目前均處於非臨牀研究階段。恆瑞將主導這些項目的研發,最晚至完成包括海外受試者數據的Ⅰ期臨牀試驗。

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