華海藥業(600521.SH):下屬子公司獲得藥物臨牀試驗許可
格隆匯1月16日丨華海藥業(600521.SH)公佈,公司的下屬子公司上海華奧泰生物藥業股份有限公司(簡稱“華奧泰”)收到美國食品藥品監督管理局(稱“美國FDA”)批准,在美國開展HB0056注射液I期臨牀試驗,HB0056是以抗TSLP人源化單克隆抗體為親本抗體,在N端連接抗IL-11單鏈納米抗體的雙特異性抗體,能高特異性地靶向TSLP和IL-11這兩個靶點。研究表明,TSLP在多種炎症性皮膚病及呼吸系統疾病的發病中發揮重要作用。IL-11是一種具有多效性的細胞因子,參與多種自免疾病及腫瘤的發生和發展。TSLP和IL-11均以不同的機制參與誘導Th2反應、氣道炎症和哮喘的發病機制,兩者可以互補作用來影響該疾病。同時阻斷TSLP和IL-11通路可以為哮喘患者提供更好的療效,特別是對於那些在不受控制的炎症後發生氣道重塑和纖維化的患者。
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