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羅欣藥業(002793.SZ):子公司替戈拉生片新適應症獲得藥品註冊證書
格隆匯 10-21 16:25

格隆匯10月21日丨羅欣藥業(002793.SZ)公佈,近日,公司下屬子公司山東羅欣藥業集團股份有限公司收到國家藥品監督管理局核准簽發的適應症為"與適當的抗生素聯用以根除幽門螺桿菌"的替戈拉生片《藥品註冊證書》。

替戈拉生片是鉀離子競爭性酸阻滯劑類藥物(Potassium-Competitive Acid Blockers,P-CAB),其抑制酸分泌的作用機制為競爭性結合壁細胞內H+/K+-ATP酶(質子泵)的鉀離子結合部位。與質子泵抑制劑(PPI)不同,P-CAB可直接抑制H+/K+-ATP酶,而無需在強酸環境下活化。而且,無論H+/K+-ATP酶活化與否,P-CAB均可與之結合。P-CAB與抗生素聯合用藥,通過其抑酸作用,為抗生素根除幽門螺桿菌提供最佳pH環境。

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