康寧傑瑞製藥-B(09966.HK)癌症藥物獲建議繼續進行研究
康寧傑瑞製藥-B(09966.HK)公布,有關KN046(KN046-303)治療晚期胰腺導管腺癌之III期臨床試驗,已獲獨立數據監察委員會(iDMC)通知,期中分析並無發現新增安全信號,委員會建議繼續進行研究,並進一步收集後續總生存期(OS)數據,直至最終總生存期分析。
KN046是該公司自主研發的全球性首創PD-L1/CTLA-4雙特異性抗體,同時靶向具有明顯結構差異的PD-L1及CTLA-4,可改變腫瘤微環境的定位及減少脫靶毒性。KN046在中國、美國和澳洲已開展覆蓋非小細胞肺癌、三陰性乳腺癌、食管鱗狀細胞癌、肝細胞癌、胰腺導管腺癌、胸腺癌等10餘種腫瘤的近20項不同階段臨床試驗。該等臨床試驗的結果初步顯示KN046具有良好安全性及顯著療效。
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