創勝集團-B(06628.HK)於ESMO世界胃腸道腫瘤大會公布OSEMITAMAB聯合CAPOX療效數據
創勝集團-B(06628.HK)公布,已於2023年ESMO世界胃腸道腫瘤大會上公布Osemitamab (TST001)聯合卡培他濱和奧沙利鉑(CAPOX)一線治療CLDN18.2表達水平的晚期胃╱胃食管連接部(G/GEJ)癌I/II期無進展生存期(PFS)數據。該等數據將支持於今年下半年啟動的全球關鍵性III期試驗。
TranStar102(TST001-1002)研究的64例CLDN18.2陽性胃╱胃食管連接部癌患者已入組。該等患者約佔所有胃╱胃食管連接部腺癌患者的55%。整體中位無進展生存期(PFS)為9.5個月,未觀察到CLDN18.2表達導致的明顯差異。
Osemitamab (TST001)與化療聯用,可為CLDN18.2陽性腫瘤患者,包括低 表達患者提供獲益。
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