藥明巨諾-B(02126.HK)：啟動JWATM214用於治療晚期肝細胞癌的臨牀研究
格隆匯2月28日丨藥明巨諾-B(02126.HK)宣佈其已啟動JWATM214用於治療晚期肝細胞癌(「HCC」)的臨牀研究，並已完成首例患者的回輸治療。
原發性肝癌是全球範圍內常見的消化系統惡性腫瘤，惡性程度高，預後差。原發性肝癌的病理類型以HCC為主，佔原發性肝癌的85%–90%。中國是全世界原發性肝癌發病率和死亡率最高的國家，每年新發病例46.6萬人，死亡42.2萬人。基於現有治療方案，患者在一線和二線治療後的中位無進展生存期約為6個月，獲益有限。因此，亟需開發針對復發轉移性晚期HCC患者的有效治療方式。
本研究為JWATM214的首次人體研究，旨在評估JWATM214在磷脂醯肌醇蛋白聚糖-3("GPC-3")表達陽性的晚期HCC成人患者中的安全性、耐受性，並確定II期推薦劑量(RP2D)，同時也將評估JWATM214在晚期HCC患者中的藥代動力學特徵，並初步觀察療效。
GPC-3在HCC等許多惡性腫瘤中過表達，已成為HCC診斷和治療的靶點。已有文獻報導初步證實了靶向GPC-3的T細胞免疫療法用於治療HCC患者的可行性。JWATM214是藥明巨諾基於優瑞科的ARTEMIS®平台及Lyell的T細胞抗衰竭技術，自主開發的一款靶向GPC-3的自體T細胞免疫治療候選藥物。它結合了GPC-3單克隆抗體的高親和力和高特異性優勢，並在JWATM204的基礎上，加入了cJun蛋白調控，以延緩T細胞衰竭，從而獲得更持久、更優的抗腫瘤活性，有望為GPC-3表達陽性的晚期HCC患者提供全新的治療選擇。
藥明巨諾於2020年分別與優瑞科及Lyell達成協議，分別獲得優瑞科的ARTEMIS?技術及Lyell T細胞抗衰竭技術的授權許可，以用於在中國(包括中國內地、香港、澳門及台灣)及東南亞國家聯盟成員國開發、生產及商業化相關產品。
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