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鍵凱科技(688356.SH):注射用聚乙二醇伊立替康用於治療腦膠質瘤II期臨牀試驗完成首例受試者入組
格隆匯 11-11 15:39

格隆匯11月11日丨鍵凱科技(688356.SH)公佈,近日,公司全資子公司天津鍵凱科技有限公司自主研發的注射用聚乙二醇伊立替康(藥物代碼:JK-1201I)聯合替莫唑胺用於腦膠質瘤治療的臨牀研究已成功完成首例受試者入組。

聚乙二醇伊立替康是公司自主研發的小分子長效抗癌1類創新藥物,該藥物是將伊立替康以聚乙二醇進行修飾後得到的新型化學藥品。目前注射用聚乙二醇伊立替康治療實體瘤適應症正在進行II臨牀試驗。

本次藥品申報擬開展適應症為腦膠質瘤的臨牀試驗。腦膠質瘤是指起源於腦神經膠質細胞的腫瘤,是最常見的原發性顱內腫瘤。目前對於膠質瘤的治療,包括手術、放療、化療、靶向治療等手段。已開展的非臨牀研究的實驗結果表明,JK-1201I具有顯著、廣譜的抗腫瘤活性,藥效優於同樣給藥方案的鹽酸伊立替康,毒性低於鹽酸伊立替康。

截至本公吿日,全球未有同類型同適應症的藥品上市。

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