君實生物(01877.HK)旗下口服藥治療中重度新冠肺炎完成首例給藥
君實生物(01877.HK)公布,控股子公司君拓生物與旺山旺水合作開發的VV116已啟動一項在中重度新型冠狀病毒肺炎受試者中評價VV116對比標準治療的有效性和安全性的國際多中心、隨機、雙盲、對照III期臨床研究,並已完成首例患者入組及給藥。
公司指,VV116是一款新型口服核(甘)類抗新型冠狀病毒藥物,可抑制新型冠狀病毒複製。臨床前研究顯示,VV116在體內外都表現出顯著的抗新型冠狀病毒作用,對新型冠狀病毒原始株和已知重要變異株(Alpha、Beta、Delta和Omicron)均表現出抗病毒活性,同時具有很高的口服生物利用度和良好的化學穩定性。
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