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聖諾醫藥-B(02257.HK)將在2022年寡核苷酸和精準醫療大會公佈其基於GalNAc的肝靶向遞送平台和產品管線的最新進展
格隆匯 03-15 07:04

格隆匯3月15日丨聖諾醫藥-B(02257.HK)發佈公吿,Sirnaomics將於2022年3月15日在美國波士頓OPT會議上公佈其GalNAc-肝臟靶向技術平台的最新進展和相關產品管線拓展。

根據披露,Sirnaomics專有的GalNAc偶聯物遞送平台依賴於短肽偶聯物和╱或獨特的RNA結構,可以敲低單個或多個不同的mRNA靶標。該公司的GalAhead™遞送平台將GalNAc靶向分子與獨特的RNAi觸發器結構結合,可以同時靶向一個(mxRNA™)或多個(muRNA™)基因的mRNA分子。Sirnaomics首席技術官Dmitry Samarsky博士將通過演講,提供數據證明mxRNA在原代肝細胞(體外)和小鼠(體內)中的功效。他還將介紹一項為期33周的非人類靈長類動物研究結果,該研究使用Sirnaomics領先的GalAhead™治療項目STP122G的候選藥物分子,靶向凝血因子XI,並報吿基於GalAhead™的其他治療項目取得的進展。

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