歌禮制藥(01672.HK):其口服藥對新冠病毒療效勝Molnupiravir 或提前申請臨牀試驗
歌禮制藥-B(01672.HK)公佈,旗下口服雙前藥ASC10及其抗病毒核(甘)類似物ASC10-A,在抑制包括Omicron在內的多種新型冠狀病毒變異病毒株的體內和體外積極數據,指通過採用雙前藥策略,ASC10在Caco-2細胞(人結直腸腺癌細胞)中的滲透性和在猴子中的口服生物利用度分別是莫努匹韋(Molnupiravir)的3.2倍和2.3倍。
基於猴子和人之間的藥物暴露量關聯關係,預計口服雙前藥ASC10在患者中具有更高的藥物暴露量,ASC10在臨牀試驗中對新型冠狀病毒的療效可能比莫努匹韋(Molnupiravir)更好。
公司表示,基於該數據,向中國、美國等國家提交臨牀試驗申請的時間可能早於公司原先預期。
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