和黃醫藥(00013.HK)治療淋巴瘤藥物啓動臨牀試驗
和黃醫藥(00013.HK)公佈,啓動一項HMPL-760的I期臨牀試驗。HMPL-760是一種可長時間結合靶點的高效、選擇性和可逆性的布魯頓酪氨酸激(酉每)(BTK)(包括野生型和C481S突變型BTK)抑制劑。首名患者已於1月4日接受給藥治療。
該研究是一項多中心、開放標籤的臨牀試驗,旨在評估HMPL-760的安全性、耐受性、藥代動力學、藥效學和初步療效。該研究正在招募既往接受過治療的慢性淋巴細胞白血病/小淋巴細胞淋巴瘤(CLL/SLL)或其他類型的非霍奇金淋巴瘤(NHL)患者,包括既往接受過含BTK抑制劑治療的野生型BTK或因新出現的BTK突變而對第一代BTK抑制劑產生獲得耐藥性的患者。
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