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中生製藥(01177.HK):創新藥"TCR1672"獲批臨牀試驗
格隆匯 12-21 12:13

格隆匯12月21日丨中國生物製藥(01177.HK)宣佈,集團自主研發的二代高選擇性P2X3抑制劑"TCR1672"已獲得中國國家藥品監督管理局簽發藥物臨牀試驗批准通知書,同意在國內開展難治性慢性咳嗽(RCC)的臨牀試驗。

P2X3受體是嘌呤類受體家族中的配體門控離子通道。研究顯示,P2X3受體的過度活化與感覺神經元的超敏化(hyper-sensitization)有關。損傷或感染引發的氣道和肺部神經元超敏反應可引起過度、持續和頻繁地咳嗽。TCR1672通過阻斷三磷酸腺苷(ATP)啟動P2X3受體產生的鈣離子內流,從而發揮對其特異性抑制作用來起到治療效果。臨牀前研究顯示,TCR1672不僅可以顯著減少難治性慢性咳嗽患者的咳嗽次數,對緩解子宮內膜異位症患者的痛楚亦有明顯作用。集團將繼續探索TCR1672在神經病理性疼痛、癌性疼痛上的應用。

公吿稱,TCR1672臨牀試驗的啟動,將進一步豐富集團在呼吸領域和疼痛領域的創新產品管線,為廣大患者帶來新的治療希望。

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