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康方生物-B(09926.HK)自主研發藥品澳洲完成首例患者給藥
阿思達克 10-22 09:49
康方生物-B(09926.HK)公佈,公司自主研發的TIGIT單克隆抗體,聯合公司的凱得寧(PD-1/CTLA-4雙特異性抗體)治療晚期或轉移性實體瘤的I期臨牀研究在澳洲完成首例患者給藥。臨牀研究顯示TIGIT單抗聯合PD-1單抗在腫瘤免疫治療中的良好臨牀獲益。凱得寧同時靶向PD-1和CTLA-4兩個成熟的免疫檢查點分子。臨牀前研究並表明,AK127和凱得寧的組合在小鼠模型中產生了顯着增強的抗腫瘤效果。
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