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君实生物(688180.SH):PD-1/TGF-β双功能融合蛋白JS201注射液获批上市
格隆汇 05-06 16:55

格隆汇5月6日丨君实生物(688180.SH)公布,近日,公司收到国家药品监督管理局核准签发的《药物临床试验批准通知书》,PD-1/TGF-β双功能融合蛋白JS201注射液(项目代号“JS201”)的临床试验申请获得批准。

JS201是公司自主研发的能同时靶向PD-1和TGF-β(转化生长因子-β)的双功能融合蛋白。肿瘤微环境中PD-1和TGF-β通常会同时高表达,TGF-β通过抑制免疫反应,介导抗PD-1单抗的原发性耐药,在癌症进展中产生重要影响。

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