百濟神州(06160.HK)啟動一項針對在研抑制劑之1期臨床試驗
百濟神州(06160.HK)公布,一項針對其在研造血幹細胞激(酉每)1(HPK1)抑制劑BGB-15025的1期臨床試驗已完成首例患者給藥。HPK1是T細胞受體(TCR)信號通路下游的一種激(酉每),被認為在啟動T細胞的過程中起到關鍵作用。BGB-15025被設計旨在成為一款高強度、高選擇性的HPK1小分子口服抑制劑。
這項人體首次1期臨床試驗(NCT04649385)旨在評估BGB-15025作為單葯或聯合百澤安在晚期實體瘤患者中的安全性、耐受性、藥物代謝動力學狀況和初步抗腫瘤活性。該試驗將在全球多個國家進行。
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