康方生物(09926.HK)公布自研藥物AK104之最新臨床研究結果
康方生物(09926.HK)公布,公司核心自主研發的、全球首創的新型腫瘤免疫治療雙特異性抗體新藥Cadonilimab(PD-1/CTLA-4雙特異性抗體,研發代號:AK104)聯合化療一線治療晚期胃癌或胃食管結合部腺癌的Ib/II期臨床研究最新結果在2021年國際胃腸道癌症研討會上發佈。
研究的安全性結果顯示,與Cadonilimab或化療相關的3級及以上不良反應發生率為38.9%,其中3級及以上與免疫相關的不良反應發生率為7.4%。研究顯示,Cadonilimab10毫克╱千克每兩星期一次(Q2W)聯合化療一線治療GC或GEJ顯示出良好的安全性和耐受性。與化療聯合一線治療GC或GEJ,Cadonilimab在各劑量水平下均表現出令人鼓舞的抗腫瘤活性、持續的腫瘤應答,並可改善晚期GC患者的無進展生存期。
目前,Cadonilimab聯合化療一線治療GC或GEJ的III期研究正在計劃中。Cadonilimab佈局的主要適應症還包括肝癌、宮頸癌、肺癌、食管鱗癌及鼻咽癌等。
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