亞盛醫藥(06855.HK)將獲MDM2蛋白降解劑之全球獨家權益
亞盛醫藥-B(06855.HK)公布,公司與密西根大學達成協議,將獲得一項基於蛋白降解靶向嵌合體(Proteolysis-Targeting Chimeras, PROTACs)技術開發的MDM2蛋白降解劑的全球獨家權益。該臨床候選物已進入IND申報試驗階段。
MDM2是腫瘤抑制因子p53的關鍵負調節因子,是迄今為止發現的最強的凋亡抑制因子之一,在腫瘤中高表達,對腫瘤的發生和發展起到重要的作用。
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