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金斯瑞生物科技(01548.HK)附屬將在ASH年會公佈CARTITUDE-1和LEGEND-2兩項研究最新資料
格隆匯 11-05 08:33

格隆匯 11 月 5日丨金斯瑞生物科技(01548.HK)發佈公告,公司附屬子公司傳奇生物科技股份有限公司在第62屆美國血液學會(“ASH”)年會將分別公佈CARTITUDE-1和LEGEND-2兩項研究的最新資料。ASH年會將於2020年12月5日至12月8日通過虛擬會議舉行。

以上研究資料的摘要將在相關的日期及時間報告。口頭報告期間將展示CARTITUDE-1的某些更新資料,重點介紹靶向B細胞成熟抗原(“BCMA”)的嵌合抗原受體T細胞(“CAR-T”)療法(西達基奧侖賽,Ciltacabtagene Autoleucel;cilta-cel)在治療復發或難治性多發性骨髓瘤的1b/2期臨牀研究中的療效和安全性結果。

根據披露,CARTITUDE-1 (MMY2001, NCT03548207)是一項正在美國和日本開展的關於西達基奧侖賽的1b/2期註冊臨牀研究,納入滿足以下條件的多發性骨髓瘤患者:1)既往至少接受3線治療或者蛋白酶體抑制劑和免疫調節劑雙重耐藥;2)既往接受過PI、IMiD和抗CD38抗體;3)最後一次治療開始後12個月內疾病進展。此外,LEGEND-2 (NCT03090659)是一項正在開展的單臂、開放性的I期臨牀研究。該研究納入了來自中國4家參與醫院的74例受試者,評估LCAR-B38M CAR-T治療復發或難治性多發性骨髓瘤的療效和安全性。 

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