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绿叶制药(02186.HK)镇痛药获中国临床试验批件
阿思达克 03-31 12:16
绿叶制药(02186.HK)公布,集团1类新药LPM3480392注射液已获中国国家药品监督管理局药品审评中心批准开始临床试验。

集团指,LY 03014是一种小分子Gi蛋白偏向性MOR激动剂,拟用於手术後中到重度疼痛和癌性爆发痛的治疗。已经完成的药效动力学和药代动力学研究显示,该产品能够显着的抑制疼痛,并减少呼吸抑制、便秘和阿片类药物耐受的发生;已经完成的毒理学研究和心血管系统长时程遥测试验显示,该产品亦没有引起肝脏毒性和心脏QT间期的变化。

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