加科思-B(01167.HK):SHP2抑制劑SITNEPROTAFIB聯用研究數據發表於學術期刊
格隆匯5月9日丨加科思-B(01167.HK)發佈公吿,公司自主研發的SHP2抑制劑sitneprotafib (JAB-3312)相關研究見刊Clinical Cancer Research(《臨牀腫瘤研究》)。文章公佈了SHP2抑制劑與PD-1抗體以及靶向RTK/RAS/MAPK通路的聯合療法中的臨牀前體內外數據和對聯合療法有迴應的代表性患者病例。
研究表明sitneprotafib顯著增強了KRAS G12C抑制劑戈來雷塞在未接受治療和耐藥模型中的抗腫瘤活性。Sitneprotafib與MEK抑制劑聯合用藥可顯着延緩RTK信號的再啟動,並增強KRAS突變癌症模型中的腫瘤生長抑制。Sitneprotafib與奧希替尼聯合用藥在奧希替尼耐藥的非小細胞肺癌(NSCLC)模型中表現出優異的療效。此外,sitneprotafib通過促進抗腫瘤微環境增強了PD-1抗體的療效。
目前,加科思正在開展sitneprotafib與戈來雷塞聯用的三期臨牀試驗,這標誌着sitneprotafib 是全球首個進入三期臨牀試驗的SHP2抑制劑。
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