來凱醫藥-B(02105.HK):LAE102針對肥胖症治療的I期多劑量遞增研究完成首例受試者訪視
格隆匯3月26日丨來凱醫藥-B(02105.HK)發佈公告,集團在中國開展的LAE102針對肥胖症治療的I期多劑量遞增研究(“MAD研究”)已啓動受試者招募。截至本公告日期,首例受試者完成了首次訪視。
MAD研究是一項隨機、雙盲、安慰劑對照研究,旨在評估皮下給藥的LAE102在60名超重╱肥胖受試者中的安全性、耐受性、藥代動力學和藥效動力學。集團致力於將這種精準治療帶給那些需要新型治療選擇以實現高質量體重控制的超重和肥胖症患者。
LAE102是自主研發針對ActRIIA的單克隆抗體,ActRIIA是在肌肉再生和脂肪代謝中發揮重要作用的受體。在臨牀前模型中,LAE102已顯示出增加肌肉並減少脂肪的效果。LAE102與GLP-1受體激動劑聯用可進一步減少脂肪並顯著降低GLP-1受體激動劑導致的肌肉流失,使LAE102成爲一種高質量體重控制候選藥物。
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