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澤璟製藥(688266.SH):披露注射用ZG006 獲得藥物臨牀試驗批准通知書
格隆匯 07-30 16:00

格隆匯7月30日丨澤璟製藥(688266.SH)公佈,公司於近日收到國家藥品監督管理局核准簽發的《藥物臨牀試驗批准通知書》,注射用ZG006用於治療晚期實體瘤的臨牀試驗獲得批准。

ZG006是一種針對CD3及兩個不同DLL3表位的三特異性抗體。ZG006的抗DLL3端與腫瘤細胞表面不同DLL3表位相結合,抗CD3端結合T細胞。ZG006銜接腫瘤細胞和T細胞,將T細胞拉近腫瘤細胞,從而利用T細胞特異性殺傷腫瘤細胞。臨牀前研究結果顯示,ZG006在小鼠腫瘤模型上具有顯著的腫瘤抑制作用,可以導致顯著比例的小鼠腫瘤完全消退,説明ZG006具有強效的腫瘤殺傷作用。

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