君實生物(01877.HK):VV116片在RSV多個敏感細胞繫上具優異抗病毒效果
君實生物(01877.HK)公佈,子公司「君拓生物」與「旺山旺水」合作開發的口服核(甘)類抗SARS-CoV-2藥物VV116片作爲潛在呼吸道合胞病毒抑制劑的臨牀前體內藥效研究成果。研究發現,VV116在RSV多個敏感細胞繫上具有優異的抗病毒效果。
在小鼠模型上,VV116具有較高的口服生物利用度、良好的組織分佈和顯着優於利巴韋林的抗病毒效果,且能緩解肺部組織的病理損傷情況。該研究爲治療RSV感染提供了有價值的臨牀候選藥物。
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