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甘李藥業(603087.SH):GZR18中國I期臨牀試驗完成首例受試者入組
格隆匯 12-10 17:35

格隆匯12月10日丨甘李藥業(603087.SH)公佈,公司自主研發的GZR18正在開展中國I期臨牀試驗,於近日成功完成首例受試者入組。

GZR18為每週注射一次的胰高血糖素樣肽1(GLP-1)受體激動劑類藥物,本次臨牀試驗擬開發適應症為2型糖尿病、肥胖及超重。

胰高血糖素樣肽-1(GLP-1)可以調節多種調控血糖激素的分泌,以葡萄糖依賴性的方式促進胰島素分泌和抑制胰高血糖素釋放,而這些在2型糖尿病患者中是受損的。

與胰島素注射劑相比,GLP-1受體激動劑具有兩個特點。首先,由於GLP-1促進胰島素分泌呈葡萄糖濃度依賴性,因此相較於胰島素注射劑,GLP-1受體激動劑類(GLP-1RA)降糖藥可以降低低血糖發生率。其次,由於GLP-1可以引起食慾下降、胃排空速度減慢、以及飽腹感增加等效應,所以它具有減輕體重的效果。

截至 2021年9月30日,甘李藥業在該項目中累計投入研發費用5812萬元人民幣。

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