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嘉和生物-B(06998.HK):GB492 I/IIa期臨牀試驗於中國完成首例患者給藥
格隆匯 09-16 12:25

格隆匯9月16日丨嘉和生物-B(06998.HK)宣佈,GB492(干擾素基因刺激因子Stimulatorof interferon genes,STING激動劑)的I/IIa期臨牀試驗已於中國完成首例患者給藥。該臨牀試驗的目的在於評價GB492在患有難治性或不適合接受標準治療的晚期惡性腫瘤成人中的安全性和初步有效性,並確定GB492單藥以及聯合重組抗PD-1人源化單克隆抗體(GB226)治療的II期推薦給藥劑量(RP2D)。

公吿稱,GB492(干擾素基因刺激因子Stimulator of interferon genes,STING激動劑)是癌細胞固有免疫感知的主要介導體,由集團於2020年6月向ImmuneSensorTherapeutic獲得獨家許可協議。STING激動劑,作為一種免疫刺激療法,將進一步增加癌症患者對免疫檢查點抑制劑的反應。多項研究顯示,STING激動劑與其他免疫檢查點抑制劑(ICI)聯合使用可激活cGAS-STING信號通路,顯著增強腫瘤免疫週期的療效,將成為一種潛在的創新療法。

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