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信達生物(01801.HK)納斯達克上市公司Bolt達成協議利用Boltbody™新型免疫療法聯合開發三款ISAC藥物
格隆匯 08-27 06:34

格隆匯8月27日丨信達生物(01801.HK)發佈公吿,公司與Bolt Biotherapeutics, Inc.(納斯達克股票代碼:BOLT),一家處於臨牀階段的生物技術公司,開創了一種能有效結合抗體靶向的精確性與先天性和適應性免疫系統的新型免疫療法,達成新藥研究開發協議,將共同開發三款治療腫瘤的抗體-免疫刺激偶聯物(“ISAC”)候選藥物。Boltbody ISAC平台由靶向腫瘤抗體、穩定且不可降解的連接子(linker)和專有免疫刺激劑組成,結合了抗體靶向腫瘤的精確性與先天性和適應性免疫系統反應的作用。

根據協議條款,公司將擁有三個合作項目的大中華區權益,同時保留其中一個項目的全球權益、另一項目除北美外區域權益的選擇權。Bolt保留其中一個項目除大中華外區域權益的選擇權和另一個項目的北美區域權益。公司將承擔至臨牀概念驗證(POC,proof-of-concept)期間的所有研發費用。在初始POC試驗數據經審核後,雙方有權根據每個項目行使在各自區域繼續開發和商業化的授權選擇權。協議簽署後,Bolt將從公司獲得500萬美元的現金首付款和潛在未來不超過1000萬美元的股權投資。此外,在各自區域達到開發及銷售里程碑後,兩家公司均有資格獲得相應的里程碑付款和特許權使用費。

通過這項研究開發合作,公司將利用專有抗體藥物組合和未披露腫瘤靶點的研發能力,結合Bolt先進的ISAC技術和髓樣細胞領域專長,開發三款新型免疫治療藥物,有望為患者帶來顯着獲益。

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