海思科(002653.SZ):獲得創新藥環泊酚注射液的藥品註冊證書
格隆匯 12 月 17日丨海思科(002653.SZ)公佈,公司全資子公司遼寧海思科製藥有限公司(“遼寧海思科”)於近日收到國家藥品監督管理局(“藥監局”)核准簽發的《藥品註冊證書》,藥品名稱為環泊酚注射液。
環泊酚注射液屬於靜脈麻醉藥,其活性成分環泊酚是(R)-構型異構體小分子藥物,為GABAA受體激動劑,通過作用於GABAA受體介導的氯離子通道,增加電流的傳導,引起神經元的超極化。這種超極化引起了神經信號傳遞一致,降低了動作電位產生的成功率,從而抑制中樞神經系統,產生麻醉的作用。
環泊酚注射液整體安全性耐受性良好,藥效活性約為丙泊酚的5倍,快速平穩起效,甦醒迅速且完全,注射痛發生率極低,對呼吸的影響優於丙泊酚,對心率和血壓的影響不劣於丙泊酚,脂質輸入量小於丙泊酚。
據米內網數據,丙泊酚2019年在中國城市公立醫院、縣級公立醫院終端銷售額超過55億元人民幣(包含丙泊酚中長鏈脂肪乳19.43億元)。
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