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君實生物(688180.SH):JS006注射液臨牀試驗申請獲受理
格隆匯 11-26 18:19

格隆匯11月26日丨君實生物(688180.SH)公佈,近日,公司收到國家藥監局核准簽發的《受理通知書》,公司產品JS006注射液(項目代號“JS006”)的臨牀試驗申請獲得受理。

JS006是公司自主研發的特異性抗人TIGIT的重組人源化IgG4κ單克隆抗體。臨牀前研究結果表明,JS006可特異性阻斷TIGIT-PVR抑制通路,同時TIGIT競爭性配體CD226與PVR結合,刺激殺傷性免疫細胞活化,分泌腫瘤殺傷性因子。TIGIT(T cell immunoglobulin and ITIM domain,T細胞免疫球蛋白和TIIM結構域)是新興的NK細胞和T細胞共有的抑制性受體,可與腫瘤細胞上高表達的PVR受體相互結合,介導免疫反應的抑制信號,從而直接抑制NK細胞和T細胞對腫瘤細胞的殺傷作用,效果類似於PD-1對T細胞的抑制作用。多項臨牀前的試驗結果顯示抗TIGIT抗體與抗PD-1/PD-L1抗體可發揮協同抗腫瘤作用。兩者結合是一種有前途的抗癌治療策略,有望增加患者對免疫治療的反應,擴大可能受益人羣的範圍。

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