和黄医药於中国启动恶性血液肿瘤抑制剂产品一期临床试验
和黄医药公布,於中国启动抑制剂产品「HMPL-306」的一期临床试验,首名患者已於7月24日接受给药治疗。
该产品为靶向异柠檬酸脱氢(酉每)(IDH)1和2突变的新型双重小分子抑制剂,是和黄医药自主研发的第9个肿瘤创新药物,用於治疗恶性血液肿瘤患者。是次试验旨在评估HMPL-306在伴有IDH1和/或IDH2突变的复发性或难治性恶性血液肿瘤患者中的安全性、药代动力学、药效学和疗效,有望为具有IDH突变的癌症患者提供治疗效益,并可能解决因亚型转化导致的IDH抑制获得性耐药问题。
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