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恆瑞醫藥(600276.SH):注射用瑞康曲妥珠單抗、阿得貝利單抗注射液納入擬突破性治療品種公示名單

格隆匯8月11日丨恆瑞醫藥(600276.SH)公佈,子公司蘇州盛迪亞生物醫藥有限公司、上海盛迪醫藥有限公司的注射用瑞康曲妥珠單抗(SHR-A1811)、阿得貝利單抗注射液被國家藥品監督管理局藥品審評中心納入擬突破性治療品種公示名單,公示期7日,這也是瑞康曲妥珠單抗第9次納入擬突破性治療品種公示名單。

注射用瑞康曲妥珠單抗可通過與HER2表達的腫瘤細胞結合並內吞,在腫瘤細胞溶酶體內通過蛋白酶剪切釋放毒素,誘導細胞週期阻滯從而誘導腫瘤細胞凋亡。阿得貝利單抗注射液是公司自主研發的人源化抗PD-L1單克隆抗體,能通過特異性結合PD-L1分子從而阻斷導致腫瘤免疫耐受的PD-1/PD-L1通路,重新激活免疫系統的抗腫瘤活性,從而達到治療腫瘤的目的。

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