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健康元(600380.SH):利用天然產物生物合成途徑的人工智能方法預測了芳香族氨基酸代謝副產物關鍵基因
格隆匯 05-11 15:12

格隆匯5月11日丨健康元(600380.SH)在業績説明會上表示,公司以健康元生物醫藥研究院作為合成生物學的研發平台,主要包括大腸桿菌、絲狀真菌、釀酒酵母以及鏈黴菌的改造、設計等。公司正在搭建自主可控的知識庫,利用AlphaFold2算法完成CPC代謝通路上關鍵酶蛋白結構預測工作,並利用天然產物生物合成途徑的人工智能方法預測了芳香族氨基酸代謝副產物關鍵基因。在頭孢菌素CPC、多拉菌素、阿卡波糖、多殺菌素、紅黴素、維生素B2、左旋多巴、α-熊果苷、L-色氨酸、L-酪氨酸、α-硫辛酸等工業菌種選育和生產工藝提升方面均取得階段性進展。截至2023年底,健康元生物醫藥研究院累計共申請國家發明專利14項(授權發明專利4項),申請實用新型專利8項(授權實用新型專利4項),獲得軟件著作權1項,發表高水平學術論文2篇。

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