亞盛醫藥-B(06855.HK)達成臨牀合作協議,將推進APG-2575聯合CDK4/6抑制劑愛博新®用於治療轉移性ER陽性HER2陰性乳腺癌的研究
格隆匯11月8日丨亞盛醫藥-B(06855.HK)宣佈,公司與輝瑞公司達成臨牀合作及供藥協議,雙方將共同開發亞盛醫藥Bcl-2選擇性抑制劑Lisaftoclax (APG-2575)聯合輝瑞的CDK4/6抑制劑愛博新®(哌柏西利),用於治療複發性、局部晚期或轉移性雌激素受體陽性(ER+)、人表皮生長因子受體2陰性(HER2-)乳腺癌的治療。
根據協議條款,亞盛醫藥將負責開展該項研究,輝瑞將負責提供研究所需的藥物。該項全球性、多中心、開放標籤的Ib/II期劑量擴展爬坡研究旨在評估lisaftoclax聯合哌柏西利在轉移性乳腺癌患者中的安全性、耐受性和抗腫瘤活性。
APG-2575是亞盛醫藥的在研新型口服Bcl-2選擇性小分子抑制劑,通過選擇性抑制Bcl-2蛋白來恢復腫瘤細胞程序性死亡機制(細胞凋亡)。在全球範圍內,APG-2575是繼VENCLEXTA® (venetoclax)之後為數不多的幾個已進入臨牀開發階段的Bcl-2選擇性抑制劑之一。自2021年6月以來,APG-2575單藥或聯合治療ER陽性乳腺癌或其他實體瘤的臨牀研究相繼在中國、美國獲批。亞盛醫藥此前已在美國、歐洲、中國及澳大利亞同步推進APG-2575用於治療多種血液腫瘤的臨牀開發。
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