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中生制药(01177.HK)就治疗纤维化创新药与Graviton签订海外授权合作协议
阿思达克 02-24 08:29
中国生物制药(01177.HK)公布,旗下附属公司北京泰德制药与美国Graviton Bioscience签订了海外授权合作协议,在大中华以外地区共同开发及商业化集团自主研发的治疗纤维化创新药「TDI01」。

根据该协议,视乎TDI01开发和商业化的进度,集团将可收取包括按TDI01各个临床和注册阶段的进展情况支付的首付款和研发里程金,及待TDI01上市後,於专利期内,按产品年度销售收入的特定比例支付的许可费和销售里程金等收益,最高可达合共5.175亿美元。

TDI01是全新靶点Rho/Rho相关卷曲螺旋形成蛋白激(酉每)2(ROCK2)的高选择性抑制剂,国家十三五重大新药创制品种。全新作用机制的TDI01可通过高选择性地抑制ROCK2信号通路,发挥抑制纤维化进展、抗炎和免疫调节等多重作用,在肺纤维化、肝纤维化等领域具有较好的治疗潜力。

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